• Two identical male twins (4 weeks old) both presented with difficulty breathing and severe pneumonia for the second time since birth.  Both infants were admitted to the hospital and required intubation to assist breathing. The twins have a three year old male sibling who also had recurrent infections including pneumonia as an infant but is doing well at this time.
• The family resides in an older home in which extensive renovations are being performed (removing walls, ceilings, etc.).
• On physical exam the patients were febrile and irritable. Both patients exhibited lymphadenopathy and hepatosplenomegaly.
• Aspergillus was isolated from the bronchical lavage of both patients.
• Immunodeficiency was the primary suspicision.

CBC: (Twin #1 & #2)
WBC with differential:  (Twin #1 & #2)
T,B,NK cell quantitation by Flow Cytometry (Twin #1 & #2)
More Flow Cytometry tests
 
 
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More Flow Cytometry tests

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Leukocyte Adhesion studies by Flow Cytometry
     (Twin #1)
     (Twin #2)
Chronic Granulomatous Disease (CGD) test by Flow Cytometry
        Twin #1 & #2
        Mother and twins' older brother